NeuroDNet

Find a cure for disease

through networks

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About NeuroDNet

NeuroDNet is an open source platform for constructing and analyzing neurodegenerative disease associated gene networks. This database was created to provide an interactive platform for researchers in the field to interrogate the relationship between genes implicated in neurodegenerative disorders. The current version of database includes twelve neurodegenerative diseases - Adrenomyeloneuropathy, Alzheimer disease, Amyotrophic lateral sclerosis, Ataxia-telangiectasia, Dentatorubral-pallidoluysian atrophy, Friedreich Ataxia, Frontotemporal Dementia, Huntington disease, Lewy Body Dementia, Parkinson disease, Prion disease, Progressive Supranuclear Palsy (Vasaikar et al. (2013) BMC Neuroscience).

(Last update : 27 Feb 2013)

Learn more about NeuroDNet

Construct Network

A new graphical tool for Disease gene network interaction analysis merged with NeuroDNet. A webserver for analysing deleterious mutations by molecular dynamics and simulation (ANGDelMut).

NEWS - Heterozygous rare variants in TREM2 are associated with a significant increase in the risk of Alzheimer's disease (Guerreiro et al. 2013, N Engl J Med.), Abeta oligomer accumulation is associated with ER and oxidative stress (Kondo et al. 2013, Cell Stem Cell), Myelinating oligodendrocyte progenitor cells (OPCs) were generated from human iPSCs (Wang et al. 2013, Cell Stem Cell), A C9ORF72 RAN translation product accumulates in insoluble inclusions in the brain (Ash et al. 2013, Neuron), Non-ATG-initiated translation from the expanded GGGGCC repeat directly link the FTLD/ALS-associated pathology in patients with C9orf72 hexanucleotide expansion (Mori et al. 2013, Science), Role of C9ORF72 in regulating membrane traffic through its product DENN-like 72 (Levine et al. 2013, Bioinformatics), CYP46A1 T/C polymorphism could increase the risk of AD (Li et al., 2012; J Neurology), Human neural stem cells have been shown to be affected during Parkinson's pathology due to aberrant LRRK2 (Guang-Hui Liu, 2012; Nature), Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of ß amyloid (Aß) metabolism and should be considered while attempting to predict AD at these earliest stages of the disease. (Verdile et al., 2012; Molecular Psychiatry), Insulin-like growth factor 1 (IGF1) polymorphism rs972936 is risk factor for Alzheimer's disease in Han Chinese. (Wang et al., 2012; Neurosci Lett.), IL-1ß -511C/T polymorphism might be associated with AD susceptibility was evaluated by a meta-analysis. (Yuan et al., 2012; Mol Biol Rep.), The Soluble Isoform of CX3CL1 Is Necessary for Neuroprotection in a Mouse Model of Parkinson's Disease. (Morganti et al., 2012 J Neuroscience), C9orf72 is implicated in many cases of sporadic and familial ALS and FTD (Majounie et al., 2012), A Network Diffusion Model of Disease Progression in Dementia (Raj et al., 2012), Predicting Regional Neurodegeneration from the Healthy Brain Functional Connectome (Zhou et al., 2012), Increasing MuSK Activity Delays Denervation and Improves Motor Function in ALS Mice (Pérez-García et. al. 2012)

Adrenomyeloneuropathy
Alzheimer disease
Amyotrophic lateral sclerosis
Ataxia-telangiectasia
Dentatorubral-pallidoluysian atrophy
Friedreich Ataxia
Frontotemporal Dementia
Huntington disease
Lewy Body Dementia
Parkinson disease
Prion disease
Progressive Supranuclear Palsy

NeuroDNet is supported by

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School of Biological Sciences

Systems biology group

IIT Delhi

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