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MULTIPLE SCLEROSIS
Multiple Sclerosis (MS) is a chronic inflammatory-mediated demyelinating disease. MR images of MS patients reveal destruction of the blood brain barrier by the immune cells and presence of a more diffuse neurodegenerative process. The characteristic pathological feature of MS is demyelination. This is caused by the attack of immune cells against myelin-related epitopes that destroy the myelin sheath and oligodendrocytes. The white matter of cadaver MS brains contain a high density of T-cells, B-cells, macrophages and microglia. MS manifest initially as recurrent attacks of neurological dysfunction (relapses), weakness or diminished dexterity in one or more limbs, a sensory disturbance, monocular visual loss (optic neuritis) and ataxia (Brück 2005, Hauser and Oksenberg 2006).


Genetic risk factors
Sr No.Gene ID Gene Protein Location Onset ReferenceGene Info
1
40
ACCN1
Q16515
17q12
RISK
PMID:17534430
Click
2
238
ALK
Q9UM73
2p23
RISK
PMID:17660530
Click
3
348
APOE
P02649
19q13.2
RISK
PMID:11109009
Click
4
540
ATP7B
P35670
13q14.3
RISK
PMID:16837933
Click
5
10317
B3GALT5
Q9Y2C3
21q22.3
RISK
PMID:19935835
Click
6
596
BCL2
P10415
18q21.33;
RISK
PMID:20112030
Click
7
627
BDNF
P23560
11p13
RISK
PMID:18061279
Click
8
720
C4A
P0C0L4
6p21.3
RISK
PMID:2089531
Click
9
841
CASP8
Q14790
2q33-q34
RISK
PMID:20363033
Click
10
842
CASP9
P55211
1p36.21
RISK
PMID:19359048
Click
11
857
CAV1
Q03135
7q31.1
RISK
PMID:19828204
Click
12
868
CBLB
Q13191
3q13.11
RISK
PMID:21037273
Click
13
729230
CCR2
P41597
3p21.31
RISK
PMID:14644039
Click
14
1234
CCR5
P51681
3p21.31
RISK
PMID:12451219
Click
15
50489
CD207
Q9UJ71
2p13
RISK
PMID:17952073
Click
16
10666
CD226
Q15762
18q22.3
RISK
PMID:20508602
Click
17
100133941
CD24
P25063
6q21
RISK
PMID:16900767
Click
18
958
CD40
P25942
20q12-q13.
RISK
PMID:19525955
Click
19
4179
CD46
P15529
1q32
RISK
PMID:21177319
Click
20
962
CD48
P09326
1q21.3-q22
RISK
PMID:18701576
Click
21
965
CD58
P19256
1p13
RISK
PMID:19497873
Click
22
923
CD6
P30203
11q13
RISK
PMID:20430450
Click
23
23274
CLEC16A
Q2KHT3
16p13.13
RISK
PMID:19834503
Click
24
1268
CNR1
P21554
6q14-q15
RISK
PMID:20007426
Click
25
1394
CRHR1
P34998
17q12-q22
RISK
PMID:20699326
Click
26
1493
CTLA4
P16410
2q33
RISK
PMID:15180809
Click
27
3627
CXCL10
P02778
4q21
RISK
PMID:17250724
Click
28
7852
CXCR4
P61073
2q21
RISK
PMID:20555355
Click
29
1594
CYP27B1
O15528
12q13.1-q1
RISK
PMID:20648053
Click
30
1620
DBC1
O60477
9q32-q33
RISK
PMID:17660530
Click
31
2099
ESR1
P03372
6q25.1
RISK
PMID:11342704
Click
32
7813
EVI5
O60447
1p22.1
RISK
PMID:18401352
Click
33
388650
FAM69A
Q5T7M9
1p22.1
RISK
PMID:17660530
Click
34
2212
FCGR2A
P12318
1q23
RISK
PMID:10371522
Click
35
2215
FCGR3B
O75015
1q23
RISK
PMID:10371522
Click
36
115352
FCRL3
Q96P31
1q21-q22
RISK
PMID:17617473
Click
37
112812
FDX1L
Q6P4F2
19p13.2
RISK
PMID:20112030
Click
38
2596
GAP43
P17677
3q13.1-q13
RISK
PMID:16837933
Click
39
2739
GLO1
Q04760
6p21.3-p21
RISK
PMID:17463067
Click
40
2262
GPC5
P78333
13q32
RISK
PMID:19010793
Click
41
2896
GRN
P28799
17q21.32
RISK
PMID:20463744
Click
42
2944
GSTM1
P09488
1p13.3
RISK
PMID:17437619
Click
43
9563
H6PD
O95479
1p36
RISK
PMID:19935835
Click
44
3077
HFE
Q30201
6p21.3
RISK
PMID:15955425
Click
45
3117
HLA-DQA1
P01909
6p21.3
RISK
PMID:9104579
Click
46
3119
HLA-DQB1
P01918
6p21.3
RISK
PMID:9104579
Click
47
3122
HLA-DRA
P01903
6p21.3
RISK
PMID:9104579
Click
48
3123
HLA-DRB1
P20039
6p21.3
RISK
PMID:9104579
Click
49
3383
ICAM1
P05362
19p13.3-p1
RISK
PMID:9667594
Click
50
29851
ICOS
Q9Y6W8
2q33
RISK
PMID:17481737
Click
51
64135
IFIH1
Q9BYX4
2q24
RISK
PMID:19450885
Click
52
3451
IFNA17
P01571
9p22
RISK
PMID:11197304
Click
53
3586
IL10
P22301
1q31-q32
RISK
PMID:12220699
Click
54
3592
IL12A
P29459
3q25.33-q2
RISK
PMID:20555355
Click
55
3558
IL2
P60568
4q26-q27
RISK
PMID:20594918
Click
56
3559
IL2RA
P01589
10p15-p14
RISK
PMID:20179739
Click
57
3575
IL7R
P16871
5p13
RISK
PMID:20112030
Click
58
3576
IL8
P10145
4q13-q21
RISK
PMID:16793206
Click
59
3676
ITGA4
P13612
2q31.3
RISK
PMID:17689671
Click
60
90134
KCNH7
Q9NS40
2q24.2
RISK
PMID:18285833
Click
61
23046
KIF21B
O75037
1pter-q31.
RISK
PMID:20007504
Click
62
3798
KIF5A
Q12840
12q13.13
RISK
PMID:20508602
Click
63
4155
MBP
P02686
18q23
RISK
PMID:12939427
Click
64
4277
MICB
Q29980
6p21.3
RISK
PMID:18588574
Click
65
4282
MIF
P14174
22q11.23
RISK
PMID:20233515
Click
66
79258
MMEL1
Q495T6
1p36
RISK
PMID:20574445
Click
67
4340
MOG
Q16653
6p22.1
RISK
PMID:17928868
Click
68
4508
MT-ATP6
P00846
-
RISK
PMID:18708297
Click
69
4540
MT-ND5
P03915
-
RISK
PMID:18270557
Click
70
4524
MTHFR
P42898
1p36.3
RISK
PMID:19854238
Click
71
4803
NGF
P01138
1p13.1
RISK
PMID:19063739
Click
72
4855
NOTCH4
Q99466
6p21.3
RISK
PMID:14651518
Click
73
5133
PDCD1
Q15116
2q37.3
RISK
PMID:15912506
Click
74
7941
PLA2G7
Q13093
6p21.2-p12
RISK
PMID:15081260
Click
75
5409
PNMT
P11086
17q
RISK
PMID:11958827
Click
76
5444
PON1
P27169
7q21.3
RISK
PMID:17463067
Click
77
5468
PPARG
P37231
3p25
RISK
PMID:18977277
Click
78
5698
PSMB9
P28065
6p21.3
RISK
PMID:20174631
Click
79
5724
PTAFR
P25105
1p35-p34.3
RISK
PMID:15748960
Click
80
5771
PTPN2
P17706
18p11.3-p1
RISK
PMID:18987646
Click
81
6401
SELE
P16581
1q22-q25
RISK
PMID:15979159
Click
82
10019
SH2B3
Q9UQQ2
12q24
RISK
PMID:20508602
Click
83
6556
SLC11A1
P49279
2q35
RISK
PMID:18973068
Click
84
9481
SLC25A27
B4DHR4
6p12.3
RISK
PMID:19536655
Click
85
6683
SPAST
Q9UBP0
2p24-p21
RISK
PMID:17420921
Click
86
6696
SPP1
P10451
4q22.1
RISK
PMID:15885319
Click
87
6772
STAT1
P42224
2q32.2
RISK
PMID:18338947
Click
88
6891
TAP2
Q03519
6p21.3
RISK
PMID:7759306
Click
89
55254
TMEM39A
Q9NV64
3q13.33
RISK
PMID:20007504
Click
90
7124
TNF
P01375
6p21.3
RISK
PMID:16872485
Click
91
7132
TNFRSF1A
P19438
12p13.2
RISK
PMID:20430450
Click
92
8743
TNFSF10
P50591
3q26
RISK
PMID:16040132
Click
93
7297
TYK2
P29597
19p13.2
RISK
PMID:19888296
Click
94
7410
VAV2
P52735
9q34.1
RISK
PMID:20598377
Click
95
163059
ZNF433
Q8N7K0
19p13.2
RISK
PMID:20598377
Click
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