Find a cure for disease
through networks
MULTIPLE SCLEROSIS
Multiple Sclerosis (MS) is a chronic inflammatory-mediated demyelinating disease. MR images of MS patients reveal destruction of the blood brain barrier by the immune cells and presence of a more diffuse neurodegenerative process. The characteristic pathological feature of MS is demyelination. This is caused by the attack of immune cells against myelin-related epitopes that destroy the myelin sheath and oligodendrocytes. The white matter of cadaver MS brains contain a high density of T-cells, B-cells, macrophages and microglia. MS manifest initially as recurrent attacks of neurological dysfunction (relapses), weakness or diminished dexterity in one or more limbs, a sensory disturbance, monocular visual loss (optic neuritis) and ataxia (Brück 2005, Hauser and Oksenberg 2006).
Genetic risk factors
