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NEURODEGENERATIVE DISEASES
About 12% of total deaths globally are related directly or indirectly to neurodegenerative disorders [WHO and WFN, 2004]. NDDs are characterized by the gradual and progressive loss of neuronal cells. The resulting disorder is correlated to the type and population of neuronal cells. Neurodegenerative Disorders (NDDs) page provides user to explore database under the disease assocaited gene category. Exploring the database through links provided in each of these sections will give the user an overview of this disease and information about the genes, polymorphisms and phenotypes. The different tools of the database may be used for analyzing the interactions between genes implicated in this disease.
Diseases included in database
| OMIM ID | Disease | Age range(yrs) | Inheritance | Etiology | Neuronal region afected | Characteristics | Genes |
|---|---|---|---|---|---|---|---|
| 300100 | Adrenomyeloneuropathy | All ages | X-linked | Genetic | Adrenal cortex, myelin of the CNS, Leydig cells of the testes | Defect in peroxisomal beta oxidation, accumulation of the saturated very long chain fatty acids (VLCFA) | Click |
| 104300 | Alzheimer disease | >65 | Autosomal dominant | Sporadic, Genetic | Cortex, hippocampus, basal forebrain, brain stem | Amyloid plaques and neurofibrillary tangles | Click |
| 105400 | Amyotrophic lateral sclerosis | All ages | Autosomal dominant | Sporadic | Spinal motore neurons, motor cortex | Impaired motor neurons | Click |
| 208900 | Ataxia-telangiectasia | Childhood | Autosomal recessive | Genetic | Nervous system, immune system | Cerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancy | Click |
| 125370 | Dentatorubral-pallidoluysian atrophy | 30-60 | Autosomal dominant | Sporadic, Genetic | Basal ganglia, brain stem cerebellum, spinal cord | Intranuclear inclusion | Click |
| 606829 | Friedreich Ataxia | <20 | Autosomal recessive | Genetic | Loss of neurons, extensive axon elongations associated with dorsal root ganglia, dorsal roots, dorsal columns, Clarke’s columns, spinocerebellar tracts, and pyramidal tracts | Impaired muscle coordination (ataxia) | Click |
| 600274 | Frontotemporal Dementia | <65 | Autosomal dominant | Sporadic, Genetic | Frontal and temporal cortex, hippocampus | Pick bodies | Click |
| 143100 | Huntington disease | All ages | Autosomal dominant | Genetic (Trinucleotide repeats) | Striatum, cortex, basal ganglia | Intracellular inclusions and Cytoplasmic aggregates | Click |
| 127750 | Lewy Body Dementia | >60 | Autosomal dominant | Genetic | Nervous system | Hippocampal and neocortical senile plaques | Click |
| 168600 | Parkinson disease | >65 | Multifactorial | Sporadic, Genetic | Dpoaminergic neurons of the substantia nigra pars compacta (SNpc) | Aggregated protein deposits (Lewy bodies) composed of alpha-synuclein | Click |
| 176640 | Prion disease | All ages | Autosomal dominant | Sporadic, Genetic and Infectious | Cortex, thalamus, brain stem, cerebellum | Spongiform degeneration, amyloid and other aggregates | Click |
| 601104 | Progressive Supranuclear Palsy | >60 | Autosomal dominant | Sporadic, Genetic | Subthalamic nucleus, substantia nigra, pallidum | Progressive neurological disorder of gait and balance | Click |
