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NEURODEGENERATIVE DISEASES
About 12% of total deaths globally are related directly or indirectly to neurodegenerative disorders [WHO and WFN, 2004]. NDDs are characterized by the gradual and progressive loss of neuronal cells. The resulting disorder is correlated to the type and population of neuronal cells. Neurodegenerative Disorders (NDDs) page provides user to explore database under the disease assocaited gene category. Exploring the database through links provided in each of these sections will give the user an overview of this disease and information about the genes, polymorphisms and phenotypes. The different tools of the database may be used for analyzing the interactions between genes implicated in this disease.

Diseases included in database

OMIM ID Disease Age range(yrs) Inheritance Etiology Neuronal region afected CharacteristicsGenes
300100AdrenomyeloneuropathyAll agesX-linkedGeneticAdrenal cortex, myelin of the CNS, Leydig cells of the testesDefect in peroxisomal beta oxidation, accumulation of the saturated very long chain fatty acids (VLCFA)Click
104300Alzheimer disease>65Autosomal dominantSporadic, GeneticCortex, hippocampus, basal forebrain, brain stemAmyloid plaques and neurofibrillary tanglesClick
105400Amyotrophic lateral sclerosisAll agesAutosomal dominantSporadicSpinal motore neurons, motor cortexImpaired motor neuronsClick
208900Ataxia-telangiectasiaChildhoodAutosomal recessiveGeneticNervous system, immune systemCerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancyClick
125370Dentatorubral-pallidoluysian atrophy30-60Autosomal dominantSporadic, GeneticBasal ganglia, brain stem cerebellum, spinal cordIntranuclear inclusionClick
606829Friedreich Ataxia<20Autosomal recessiveGeneticLoss of neurons, extensive axon elongations associated with dorsal root ganglia, dorsal roots, dorsal columns, Clarke’s columns, spinocerebellar tracts, and pyramidal tractsImpaired muscle coordination (ataxia)Click
600274Frontotemporal Dementia<65Autosomal dominantSporadic, GeneticFrontal and temporal cortex, hippocampusPick bodiesClick
143100Huntington diseaseAll agesAutosomal dominantGenetic (Trinucleotide repeats)Striatum, cortex, basal gangliaIntracellular inclusions and Cytoplasmic aggregatesClick
127750Lewy Body Dementia>60Autosomal dominantGeneticNervous systemHippocampal and neocortical senile plaquesClick
168600Parkinson disease>65MultifactorialSporadic, GeneticDpoaminergic neurons of the substantia nigra pars compacta (SNpc)Aggregated protein deposits (Lewy bodies) composed of alpha-synucleinClick
176640Prion diseaseAll agesAutosomal dominantSporadic, Genetic and InfectiousCortex, thalamus, brain stem, cerebellumSpongiform degeneration, amyloid and other aggregatesClick
601104Progressive Supranuclear Palsy>60Autosomal dominantSporadic, GeneticSubthalamic nucleus, substantia nigra, pallidumProgressive neurological disorder of gait and balanceClick

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