The Vascular Biology and Cancer Laboratory investigates the impact of blood vessels (BVs) on various physiological and pathological conditions. Using techniques in cellular and molecular biology, in vitro cell culture, in vivo mouse models, and bioinformatics tools, we explore how vasculature affects heterogeneity, cellular rewiring, and metabolic reprogramming in cancer, aging, and other diseases.
Our research focuses on:
Tumor Angiogenesis : Studying new blood vessel formation in tumors, crucial for tumor growth and metastasis.
Cancer Organoids : Utilizing 3D cell culture systems that mimic the tumor microenvironment to better understand cancer biology and test treatments.
Cancer Stem Cells : Investigating the role of cancer stem cells in tumor initiation, progression, and resistance to therapy.
Tumor Hypoxia : Examining the effects of low oxygen levels in tumors on cancer cell metabolism and therapy resistance.
Spatial Heterogeneity : Exploring how variations within the tumor microenvironment influence cancer progression and treatment outcomes.
We aim to uncover genetic, epigenetic, and metabolic factors that lead to therapeutic resistance and identify new therapeutic targets. Our long-term goal is to dissect the role of BVs in cancer and other disease pathologies to design innovative therapeutic strategies. For further information and updates, please visit our lab website.